Cyclin A2, Rho GTPases and EMT
نویسندگان
چکیده
منابع مشابه
Cyclin A2, Rho GTPases and EMT
Cell cycle regulators, such as cyclins, are often upregulated in many proliferative disorders, and Cyclin A2 is generally considered as a marker of aggressive cancers. Our recent work, which revealed decreased expression of Cyclin A2 upon metastasis of colorectal cancer, suggests a more complicated situation. Consistent with this, we identified a role for Cyclin A2, via RhoA, in regulation of t...
متن کاملRho GTPases
Cell migration is a complex, dynamic process that involves continuous remodeling of the cellular architecture, which is needed in order for the cell to move and adapt to changes in the surrounding environment. It requires rapidly activated and spatiotemporally regulated signaling networks that enable cellular responses to external cues. Rho-family GTPases are key components of these signaling n...
متن کاملRho Gtpases
The composition of the extracellular matrix (ECM) surrounding cells is key to their behavior: it modulates their ability to proliferate, differentiate, and migrate (Giancotti and Ruoslahti, 1999). ECM components can signal directly to cells through transmembrane receptors such as inte-grins, and can also present soluble cytokines and growth factors to cells. The morphology of cells varies great...
متن کاملRho GTPases
In his review of the Ras family in 1988, Pierre Chardin speculated that an obscure subfamily of the Ras superfamily, which at that time was only known in yeast, would be conserved in mammals. He was of course right, and today the number of labs and the amount of effort being expended to understand the vast network of Rho-family signaling is enormous. Given their fundamental role in normal and d...
متن کاملRho GTPases and signaling networks.
The Rho GTPases form a subgroup of the Ras superfamily of 20to 30-kD GTP-binding proteins that have been shown to regulate a wide spectrum of cellular functions. These proteins are ubiquitously expressed across the species, from yeast to man. The mammalian Rho-like GTPases comprise at least 10 distinct proteins: RhoA, B, C, D, and E; Rac1 and 2; RacE; Cdc42Hs, and TC10. A comparison of the amin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Small GTPases
سال: 2012
ISSN: 2154-1248,2154-1256
DOI: 10.4161/sgtp.20791